Francisco Torrent-Guasp




Ventricular “Brace” prosthesis ©

External ventricular supporting device, designed according to anatomical and functional principles of the VMB concept, to abolish or reverse ventricular remodeling. Experimental research protocol has been completed (F. Torrent-Guasp and M.J. Kocica). Realization is pending the appropriate laboratory.

Electrical circulation ©

New concept on electrical events within cardiovascular system, explaining the sequence of electrical activation within the heart and its electrical coupling with blood vessels. Experimental research protocols are prepared (F. Torrent-Guasp and M.J. Kocica) to test the existence of vestigial peristalsis within circulatory system, ventriculo-arterial electrical coupling and the optimal site for the permanent pacing electrode. Initial experimental proofs, obtained in the laboratory of Prof. Anhel Benitez - Royal Academia de Medicina Universidad de Cadiz. Further research is pending the appropriate laboratory.

Mitral valve – papillary muscles dynamic complex ©

Functional anatomy of the mitral valve - papillary muscle complex. Research protocol (F. Torrent-Guasp and M.J. Kocica) designed to analyze the function of the LV papillary muscles and the importance of preserving mitral-papillary connection during the mitral valve replacement. The protocol also describe the possibility to correct the mitral and tricuspid regurgitation using the Ventricular "Brace" Prosthesis. Experimental work in pending appropriate laboratory.

Imaging techniques and the VMB concept

Analysis of the activation (contraction) sequences and movements of the VMB were done in numerous centers, by different researchers. Echocardiography, CT and MRI - Dr Francesc Carreras-Costa, Sant Pau Hospital, Barcelona, Spain;  Fourier analyses of MUGA scans (30 patients in prospective study) - Dr A. Flotats, Sant Pau Hospital, DT-MRI and DENSE-MRI - Dr Han Wen, NIH-NHLBI Laboratory of Cardiac Energetics...

Sono-micrometric analysis of VMB segmental activity

Experimental researches are done in Hospital LaFe, Valencia, Spain, in the laboratory of Prof. J. Cosin-Aguilar. Sonomycrometric analyses have proved the activation sequence along the VMB. Further researches are designed to test the role of AS contraction in diastolic suction.

Mathematical modeling of the ventricular myocardium

Ongoing research in the laboratory of Prof. Morteza Gharib, Californian Institute of Technology, Pasadena, USA.

Surgical restoration of the LV

Initial experimental and clinical proofs of the importance of preserving the VMB-AS provided in the laboratory of the Prof. Masashi Komeda, UC Kyoto, Japan. Modifications of the original Dor's procedure, preserving the size, shape and orientation of the LV developed by Prof. Gerald Buckberg and RESTORE group. Further developments in this area (Dr M.J.Kocica) in experimental testing phase.

Embryogenesis and phylogenesis of the VMB ©

Theoretical conception. Experimental research is pending.